Discusses research being done on the effects of different components and regulators of the anaphase-promoting complex or cyclosome on the degradation of cyclin A. Reference to a study by Michael Rape and Marc W. Kirschner published in a 2004 issue of "Nature"; Key components of cell-cycle machinery; Results of the accumulation of cyclin-A-CDK1 and cylin-B-CDK1 cell cycle regulators.