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- Title
Biodegradable Hydrogels Loaded with Magnetically Responsive Microspheres as 2D and 3D Scaffolds.
- Authors
Carvalho, Estela O.; Ribeiro, Clarisse; Correia, Daniela M.; Botelho, Gabriela; Lanceros-Mendez, Senentxu
- Abstract
Scaffolds play an essential role in the success of tissue engineering approaches. Their intrinsic properties are known to influence cellular processes such as adhesion, proliferation and differentiation. Hydrogel-based matrices are attractive scaffolds due to their high-water content resembling the native extracellular matrix. In addition, polymer-based magnetoelectric materials have demonstrated suitable bioactivity, allowing to provide magnetically and mechanically activated biophysical electrical stimuli capable of improving cellular processes. The present work reports on a responsive scaffold based on poly (L-lactic acid) (PLLA) microspheres and magnetic microsphere nanocomposites composed of PLLA and magnetostrictive cobalt ferrites (CoFe2O4), combined with a hydrogel matrix, which mimics the tissue's hydrated environment and acts as a support matrix. For cell proliferation evaluation, two different cell culture conditions (2D and 3D matrices) and two different strategies, static and dynamic culture, were applied in order to evaluate the influence of extracellular matrix-like confinement and the magnetoelectric/magneto-mechanical effect on cellular behavior. MC3T3-E1 proliferation rate is increased under dynamic conditions, indicating the potential use of hydrogel matrices with remotely stimulated magnetostrictive biomaterials for bone tissue engineering.
- Subjects
HYDROGELS; MICROSPHERES; TISSUE engineering; EXTRACELLULAR matrix; CELL culture; FERRITES; BIOMATERIALS
- Publication
Nanomaterials (2079-4991), 2020, Vol 10, Issue 12, p2421
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano10122421