We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Function of DSC1 in sensory-central nervous system-motor circuits of Drosophila larva.
- Authors
REN Yaxin; WEI Jiaqi; ZUO Yayun; HU Zhaonong
- Abstract
[Objective] This study investigated the role of Drosophila sodium channel 1 (DSC1) in sensory-central nervous system-motor circuit (S-CNS-MC) in Drosophila larva to provide reference for effective control of Drosophila. [Method] Taking S-CNS-MC of Drosophila melanogaster larvae as model, four Drosophila strains of w1118, parats1, DSC1-/- and parats1 ;DSC1-/- larvae with different neurogenetic backgrounds were selected. Their behaviors were studied using foraging activities of tomato slices in normal state and hungry state and the electrophysiology was studied by measuring excitatory contact points. [Result] The behavioral observation of foraging activities with tomato slices showed that there was no significant difference among strains at each observation time point under normal conditions. In hungry state, the number of 3rd larvae in the peel part of the DSC1-/- strain was significantly larger than that of other strains with the extension of time. These results indicated that the response of Drosophila larvae with DSC1 knocked out in starvation was sluggish and the foraging behavior was slow. The excitatory junction potentials (EJP) frequency of w1118 and parats1 larvae during starvation showed no significant difference from normal state, while that of DSC1-/- and parats1;DSC1-/- larvae decreased significantly under starvation condition, indicating that the excitability of S-CNS-MC in the larvae with DSC1 channel knocked out was significantly reduced under starvation condition, which was consistent with the observation of foraging behavior. [Conclusion] The DSC1 channel plays an important role in maintaining excitatory conduction and neural circuit stability of nervous system under starvation stress conditions.
- Subjects
DROSOPHILA; DROSOPHILA melanogaster; NEURAL conduction; FORAGING behavior; LARVAE; MOTOR learning; HUNGER
- Publication
Journal of Northwest A & F University - Natural Science Edition, 2023, Vol 51, Issue 6, p74
- ISSN
1671-9387
- Publication type
Article
- DOI
10.13207/j.cnki.jnwafu.2023.06.009