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- Title
Stem cell medicine encounters the immune system.
- Authors
Bradley, J. Andrew; Bolton, Eleanor M.; Pedersen, Roger A.
- Abstract
Recent progress in deriving human embryonic stem (hES) cells and defining their capacity to differentiate has inspired hope that they could become a source of replacement cells for damaged or diseased tissues. We review the immunological barriers to transplanting hES cells and consider several potential solutions, including stem-cell banking, modification of the immunogenicity of donor cells and induction of tolerance to the graft. We evaluate the probable efficacy of these approaches with a view to facilitating the use of hES cells in clinical practice.
- Subjects
EMBRYONIC stem cells; IMMUNE response; IMMUNOTECHNOLOGY
- Publication
Nature Reviews Immunology, 2002, Vol 2, Issue 11, p859
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri934