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- Title
ORDERED MESOPOROUS CARBON BASED SENSOR FOR SENSITIVE DETECTION OF VITAMIN B<sub>6</sub> IN PHARMACEUTICALS.
- Authors
APETREI, IRINA MIRELA; APETREI, CONSTANTIN; BUZIA, OLIMPIA DUMITRIU
- Abstract
A novel screen-printed sensor based on ordered mesoporous carbon was used for the electrochemically determination of pyridoxine (vitamin B6) in pharmaceuticals. Various experimental parameters were studied and optimized such as the nature and the pH of the electrolyte solution, the scanning rate and the interference of different chemical species. Optimal electroanalytical conditions are represented by: phosphate buffer (pH 7.0) with the concentration of 0.01 mol/L and the potential scanning rate of 0.1 V/s. In these conditions, interferences of the main compounds found in pharmaceuticals were less than 1%. The linearity range of the sensor in order to determine the concentration of pyridoxine was from 1 to 200 µM with a detection limit of 0.42 µM. Voltammetry was successfully applied for the quantification of vitamin B6 in pharmaceuticals. The results obtained for the ordered mesoporous carbon-based sensor were compared to those obtained by the standard spectrophotometric method resulting a very good correlation.
- Subjects
VITAMIN B6; DRUG analysis; MESOPOROUS materials; ELECTROLYTE solutions; ELECTROCHEMICAL analysis; VOLTAMMETRY
- Publication
Farmacia, 2016, Vol 64, Issue 4, p544
- ISSN
0014-8237
- Publication type
Article