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- Title
Risk Factors for Anthracycline Associated Cardiotoxicity in Iraqi Breast Cancer Patients.
- Authors
Abbas, Zaid Khudhair; Al-Zubaidy, Azher Sebieh
- Abstract
Background: Anthracyclines are among the most successful medicines for treating breast cancer; when taken in combination regimens, they enhance both disease-free and overall survival in breast cancer patients. Unfortunately, they are the representative agents causing cardiotoxicity, particularly Left ventricular dysfunction. Aim of the study: To assess the incidence and risk factors for anthracycline-induced cardiotoxicity for early detection and prevention among breast cancer patients. Methods: Eighty-six patients with breast cancer were given Adriamycin (60 mg/m2) with cyclophosphamide (600 mg/m2), with different cycles number and frequencies. They were prospectively monitored clinically, and by echo study to detect any cardiotoxicity, several patients and drug-related risk factors were analyzed to identify their influence on Anthracycline Induced Cardiotoxicity. Results: After anthracycline chemotherapy, 21 patients (24.4%) developed diastolic dysfunction, and 7 patients (8.1%) developed reduction in the left ventricular ejection fraction more than 10%, out of these 7 patients, 4 developed symptomatic cardio toxicity. Older age (> 60 years), Hypertension, diabetes, and abnormal renal function were all associated with a higher risk for developing anthracycline cardiotoxicity. Conclusions: Cardiotoxicity is common among breast cancer patients treated with anthracycline-based chemotherapy, which can even occur in a dose less than 240mg/m2. Age older than 60, Hypertension, diabetes mellites, and abnormal renal function showed significant association with Anthracycline Induced Cardiotoxicity.
- Subjects
CANCER patients; CARDIOTOXICITY; BREAST cancer; VENTRICULAR ejection fraction; DISEASE risk factors
- Publication
Kerbala Jorunal of Medicine, 2021, Vol 14, Issue 2, p2521
- ISSN
1990-5483
- Publication type
Article