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- Title
Synthesis and evaluation of α-glucosidase inhibitory activity of sulfonylurea derivatives.
- Authors
Bui, Thi Thoi; Tran, Van Loc; Ngo, Dai Quang; Tran, Van Chien; Tran, Van Sung; Tran, Thi Phuong Thao
- Abstract
Two series of sulfonylureas derivatives including 24 compounds (4, 7, 5a–5o, 8a–8h), among them 17 new derivatives, have been synthesized and evaluated for their α-glucosidase inhibitory activity. Compounds 5c, 5h and 8e showed significant in vitro α-glucosidase inhibition with IC50 values of 5.58, 79.85 and 213.36 µm, respectively, comparing with the standard compounds acarbose (IC50 = 268.29 µm) and glipizide (IC50 = 300.47 µm). The preliminary structure-activity relationships (SARs) of the synthesized compounds were also investigated.
- Subjects
STRUCTURE-activity relationships; CHEMICAL synthesis; GLIPIZIDE; SULFONYLUREAS; ACARBOSE
- Publication
Zeitschrift für Naturforschung B: A Journal of Chemical Sciences, 2021, Vol 76, Issue 3/4, p163
- ISSN
0932-0776
- Publication type
Article
- DOI
10.1515/znb-2020-0134