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- Title
C015: Circadian variation of pulse pressure and heart rate variability in patients with essential hypertension.
- Authors
Ijiri*, H.; Kohno, I.; Iida, T.; Yin, D.F.; Takusagawa, M.; Umetani, K.; Ishihara, T.; Sawanobori, T.; Osada, M.; Ishii, H.; Komori, S.; Tamura*, K.
- Abstract
To evaluate the circadian variation of pulse pressure (PP) and heart rate variability (HRV) in essential hypertension (HTN), we performed 48-hr. ambulatory blood pressure (BP) monitoring (Colin, Japan) every 30 min. and Holter ECG recording (Del Mar Avionics, USA) in 56 untreated patients with mild to moderate HTN. Power spectral analysis of RR interval was performed from 24-hr. Holter ECG every 10 min. by the FFT method to obtain the low frequency band (LF:0.04-0.15Hz) and the high frequency band (UF: 0.15-0.40Hz). The nocturnal reduction rate (NRR) of PP was calculated according to the formula. NRR(%) = (daytime mean − nighttime mean) / (daytime mean). Mean BP and PP for 48 hrs. were 142±14 / 84±11, 65±9 mmHg, respectively. Both 24-hr. mean LF and HF correlated with 48-hr. mean PP (r = −0.30, −0.32; p<0.05), but not with the NRR of PP. Patients with 48-hr. mean PP≥60mmHg (n=43) had significantly smaller 24-hr. mean LF and HF than those (n=13) with <60mmHg (LF:4.8±0.6 vs. 5.3±0.7 msec/Hz2, HF:4.1±0.6 vs. 4.7±0.7 msec/Hz2, p<0.05). Mean LF/HF for 24-hrs. was similar in two groups. In conclusion, hypertensive patients with increased 48-hr. mean PP are likely to have more decreased HRV and parasympathetic activity, and increased mean PP might be a risk factor for autonomic dysfunction in patients with mild to moderate HTN.Am J Hypertens (2000) 13, 214A-215A; doi:S0895-7061(00)00735-4
- Publication
American Journal of Hypertension, 2000, Vol 13, p214A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(00)00735-4