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- Title
Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features.
- Authors
Lieto, Maria; Roca, Alessandro; Bruzzese, Dario; Antenora, Antonella; Alfieri, Girolamo; Saccà, Francesco; Bellofatto, Marta; Bilo, Leonilda; Barbato, Stefano; De Michele, Giuseppe; Filla, Alessandro
- Abstract
Sixty-six patients with possible or probable MSA (multiple system atrophy) cerebellar type, personally observed between 2006 and 2018 were retrospectively reviewed. The time point of data collection was January 1, 2019. Forty-nine patients lost independent walking after a median time of 5 years (95% C. I. 4-6). Thirty-two patients were confined to wheelchair after a median time of 7 years (95% C. I. 7-8). Twenty-seven patients were deceased after a median time of 9 years (95% C. I. 8-10). A later onset predicted an earlier loss of independent walking (HR 1.07; 95% C.I. 1.03-1.11; p = 0.001). Higher UMSARS score predicted shorter time to loss of independent walking (HR 1.04; 95% C.I. 1.02-1.06; p = 0.001) and to wheelchair (HR 1.03; 95% C.I. 1.01-1.06; p = 0.021). No predictor of time to death was found.
- Subjects
ITALY; MULTIPLE system atrophy; LONGITUDINAL method; COHORT analysis; DISEASE progression; NEURODEGENERATION; DISEASE complications
- Publication
Neurological Sciences, 2019, Vol 40, Issue 10, p2105
- ISSN
1590-1874
- Publication type
journal article
- DOI
10.1007/s10072-019-03948-7