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- Title
A case report of synchronous upper arm sarcoma and breast cancer.
- Authors
Nichita, Adriana-Monica; Moraru, Mihaela; Goga, Iolanda; Cioc, Enache; Ilie, Andreea; Ginghină, Octav; Mardare, Mara; Neicu, Ariana-Ştefania; Ene, Adina-Elena; Ştefănel, Vlad; Moldovan, Alina-Oana; Stănculeanu, Dana-Lucia; Gheorghe, Adelina-Silvana; Zob, Daniela-Luminiţa
- Abstract
Soft tissue sarcomas are rare tumors, accounting for less than 1% of all malignancies, while, on the contrary, breast cancer is the most common form of cancer among women. We selected the case of a 75-year-old woman presenting with a tumoral mass on the posterolateral side of the right upper arm. The MRI scan displayed a 7/4 cm lesion with no bone or muscle involvement, and the CT scan excluded lymph node involvement or distant metastasis. The histopathologic and immunohistochemical testing revealed a high-grade leiomyosarcoma diagnosis. While being evaluated for the sarcoma, another suspect lesion was discovered – a 4.5-cm mass in the lower outer quadrant of the left breast with no apparent axillary lymph node involvement. Leiomyosarcoma resection was performed together with breast tumor core needle biopsy, which revealed moderately differentiated invasive ductal carcinoma with negative hormonal receptors and positive HER2. The patient followed local upper arm radiotherapy and a neoadjuvant treatment scheme consisting of epirubicin and cyclophosphamide, followed by dual anti-HER2 therapy and platinum compound. Post-surgical assessment revealed no residual breast tumor, while the imaging studies showed no sign of upper arm recurrence and no sign of distant disease. The case highlights the importance of a thorough patient evaluation and the necessity of early detection of cancer, regardless of type or incidence, as it allows for better treatment responses and improved outcomes.
- Subjects
BREAST cancer; LOBULAR carcinoma; SARCOMA; CORE needle biopsy; BREAST tumors; EARLY detection of cancer
- Publication
Oncolog-Hematolog, 2023, Issue 64, p41
- ISSN
2066-8716
- Publication type
Article