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- Title
Hypereosinophilia in an aggressive peripheral T non-Hodgkin lymphoma – more than a hematological issue.
- Authors
Bonea, Diana Emanuela; Mambet, Cristina; Găman, Mihaela; Iordan, Iuliana; Neculcea, Andreea; Grigoroiu, Alina; Pîrvan, Patricia; Popescu, Dragoș-Claudiu; Onofrei, Alexandru; Enache, Cristina; Mihai, Stejara Nicoleta; Ferea, Cătălina; Baciu, Alexandra Maria; Vlădăreanu, Ana Maria
- Abstract
Eosinophilia is a frequent laboratory abnormality, associated with many hematological malignancies, solid tumors or with autoimmune diseases. It is most often found in Hodgkin lymphoma and in T-cell lymphoma. In T-cell lymphoma or adult’s T-cell leukemia, it is highly correlated with the peripheral leukemic cell count, disease extension and with Ann-Arbor stage. Hypereosinophilic syndrome (HES) is a heterogeneous group of clonal disorders characterized by significant eosinophilia without an underlying cause, and with clinical features due to eosinophilic infiltration of lungs, heart or serous membranes. HES can precede lymphoma’s onset, being associated with a poor prognosis. The paraclinical investigations are necessary to determine the organ damage and various cytogenetic and molecular assays are employed to identify rearrangements of PDGFRA, PDGFRB, FGFR1 or PCM1- JAK2 gene fusion. The upcoming case report describes a patient with a non-Hodgkin T-cell lymphoma associating HES, treated with multiple chemotherapeutic regimens. After each cycle, he obtained an unstable response. It was considered a highly aggressive disease with a poor prognosis and a severe evolution.
- Subjects
NON-Hodgkin's lymphoma; T-cell lymphoma; ADULT T-cell leukemia; HEMATOLOGIC malignancies; SEZARY syndrome; HYPEREOSINOPHILIC syndrome; PULMONARY eosinophilia
- Publication
Oncolog-Hematolog, 2021, Issue 57, p52
- ISSN
2066-8716
- Publication type
Article
- DOI
10.26416/onhe.57.4.2021.5803