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- Title
Inhalation of THC-containing cannabis selectively diminishes cardiac autonomic function in humans.
- Authors
Nardone, Massimo; Cheung, Christian P.; Baker, Ryleigh E.; Pfundt, Kathryn; Lee, Jordan B.; Burr, Jamie F.; Millar, Philip J.
- Abstract
This document, published in the journal Clinical Autonomic Research, explores the effects of inhaling cannabis on cardiac autonomic function in humans. The study specifically focuses on the impact of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), two primary cannabinoids found in cannabis. The researchers found that inhalation of THC-containing cannabis decreased cardiac baroreflex gain and heart rate variability, while CBD did not have the same effect. Additionally, THC increased ventricular repolarization, as indicated by changes in the QT interval. These findings suggest that the physiological effects of cannabis may be influenced by the relative proportions of THC and CBD.
- Subjects
HEART beat; CANNABINOIDS; CANNABIDIOL; BAROREFLEXES; RESEARCH personnel
- Publication
Clinical Autonomic Research, 2023, Vol 33, Issue 6, p919
- ISSN
0959-9851
- Publication type
Article
- DOI
10.1007/s10286-023-00993-3