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- Title
Greater influence of age than co-morbidity on primary treatment and complications of prostate cancer patients: an in-depth population-based study.
- Authors
Houterman, S; Janssen-Heijnen, M. L. G.; Verheij, C. D. G. W.; Kil, P. J. M.; Van den Berg, H. A.; Coebergh, J. W.
- Abstract
We investigated the influence of age and co-morbidity on treatment, the occurrence of serious non-urological complications of treatment and prognosis for prostate cancer patients diagnosed and treated in community hospitals. Additional information from a random sample of 505 prostate cancer patients (aged 40 years or older) from the Eindhoven Cancer Registry diagnosed between 1995 and 1999 was collected. In all, 43% of the prostate cancer patients aged 40–69 years and 64% of those aged 70 or older suffered from one or more serious concomitant disease that barely affected primary treatment choice. However, compared to patients without co-morbidity, patients with cardiovascular diseases underwent radical prostatectomy less often (P=0.01). In all, 38% of the patients undergoing radical prostatectomy suffered from complications during the first year after diagnosis versus about 20% of those receiving radiotherapy. The number of complications did not seem to be affected by co-morbidity. After adjustment for age, stage, grade, prostate-specific antigen level and treatment, the cumulative risk of death was almost two times higher for patients with two or more concomitant diseases than for patients without co-morbidity. After adjustment for age, prostate cancer patients with co-morbidity were not treated differently, did not suffer from more complications but had a worse prognosis, compared to those without co-morbidity.Prostate Cancer and Prostatic Diseases (2006) 9, 179–184. doi:10.1038/sj.pcan.4500868; published online 14 March 2006
- Subjects
PROSTATE cancer; CANCER treatment; CANCER radiotherapy; CANCER patients; PROSTATECTOMY; CANCER prognosis
- Publication
Prostate Cancer & Prostatic Diseases, 2006, Vol 9, Issue 2, p179
- ISSN
1365-7852
- Publication type
Article
- DOI
10.1038/sj.pcan.4500868