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- Title
Protein Biosynthesis Proofreading Is Closely Associated with the Existence of Factor-Free Ribosomal Synthesis.
- Authors
Finkelstein, A. V.; Gavrilova, L. P.
- Abstract
Despite protein biosynthesis being studied for decades, some major questions concerning this process are still to be addressed. We elucidate a close connection between proofreading of the emerging amino acid sequence during its normal, elongation factor-dependent ribosomal biosynthesis and the existence of the factor-free synthesis of a polypeptide chain on a ribosome. In this factor-free process, the biological role of proofreading is played by a process opposite to the factor-free attachment of Aa-tRNA to the ribosome, namely, the removal via the same pathway of that Aa-tRNA, which is not complementary to the mRNA codon exhibited by the ribosome.
- Subjects
BIOSYNTHESIS; AMINO acids; PROTEIN synthesis; RIBOSOMES; NUCLEOPROTEINS
- Publication
Molecular Biology, 2019, Vol 53, Issue 2, p308
- ISSN
0026-8933
- Publication type
Article
- DOI
10.1134/S0026893319020043