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- Title
Acid-sensing ion channel subtype 3 function and immunolabelling increases in skeletal muscle sensory neurons following femoral artery occlusion.
- Authors
Xing, Jihong; Lu, Jian; Li, Jianhua
- Abstract
Non-technical summary Limb ischaemia commonly occurs in peripheral artery disease and blood pressure response to stimulation of muscle afferent nerves during exercise activity is augmented in this disease; however, the mechanisms responsible for this physiological process are not well-known. In this report, expression and function of acid-sensing ion channels subtype 3 (ASIC3) in muscle afferent nerves were examined following the hindlimb ischaemia induced by femoral artery occlusion. The data provided here suggest that femoral artery occlusion increases ASIC3 expression and responsiveness in muscle sensory neurons. The results help us better understand why the blood pressure response to exercise is exaggerated in patients with peripheral artery disease.
- Subjects
ISCHEMIA; BLOOD pressure; EXERCISE; ION channels; HINDLIMB
- Publication
Journal of Physiology, 2012, Vol 590, Issue 5, p1261
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2011.221788