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- Title
Skin microbiota analysis-inspired development of novel anti-infectives.
- Authors
Liu, Yao; Liu, Yuanzhen; Du, Zixiu; Zhang, Lidan; Chen, Juan; Shen, Zhen; Liu, Qian; Qin, Juanxiu; Lv, Huiying; Wang, Hua; He, Lei; Liu, Junlan; Huang, Qian; Sun, Yuhui; Otto, Michael; Li, Min
- Abstract
Background: The alarming spread of antimicrobial resistance requires the development of novel anti-infective drugs. Despite the recent research focus on the human microbiome and its likely value to understand and exploit inter-bacterial inhibitory phenomena as a source for antimicrobial strategies, the human microbiota has barely been investigated for the purpose of drug development. Results: We performed a large screen analyzing over 3000 human skin isolates to evaluate bacterial competition within the human skin microbiota as a basis for the development of anti-infective therapeutics. We discovered a Staphylococcus hominis strain with strong and broad activity against Gram-positive pathogens that was mediated by the bacteriocin micrococcin P1 (MP1). In "probiotic" approaches, this strain led to reduced Staphylococcus aureus infection and accelerated closure of S. aureus-infected wounds. Furthermore, we used a nanoparticle strategy to overcome the physico-chemical limitations often encountered with natural substances such as MP1 and demonstrate a significant reduction of S. aureus infection by MP1-loaded nanoparticles. Conclusions: Our study gives examples of how analysis of bacterial interactions in the human microbiota can be explored for the development of novel, effective anti-infective strategies. Video Abstract
- Publication
Microbiome, 2020, Vol 8, Issue 1, p1
- ISSN
2049-2618
- Publication type
Article
- DOI
10.1186/s40168-020-00866-1