We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Method Development for Drug Impurity Profiling: Part 1.
- Authors
Dejaegher, Bieke; Dumarey, Melanie; Heyden, Yvan Vander
- Abstract
In this Practical Data Handling column, method development for drug impurity profiling is discussed. This first part consists of the first two steps when developing a drug impurity profile: the selection of a suitable chromatographic column and the optimization of the mobile phase pH. Prior to the impurity profiling, the selection of a set of dissimilar chromatographic columns is made (i.e., columns with different selectivities) to be screened with the impurity mixture for selectivity differences.
- Subjects
DRUG analysis; CHROMATOGRAPHIC analysis; HYDROGEN-ion concentration; INDUSTRIAL contamination; DRUG monitoring; PHARMACEUTICAL chemistry
- Publication
LC-GC Europe, 2010, Vol 23, Issue 4, p218
- ISSN
1471-6577
- Publication type
Article