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- Title
Analysis of Polymers and Protein Nanoparticles using Asymmetrical Flow Field-Flow Fractionation (AF4).
- Authors
Schultes, Stephan; Mathis, Kathrin; Zillies, Jan; Zwiorek, Klaus; Coester, Conrad; Winter, Gerhard
- Abstract
Gelatin nanoparticles are used as a novel, biodegradable and well-tolerated drug carrier in tumour therapy and numerous other diseases. For a valid formulation approach in clinical studies an in-depth understanding of the molecular weight characteristics of this biopolymer is essential. Asymmetrical Flow Field Flow Fractionation (AF4) analysis was shown to be a fast and reliable analysis method for the pre-formulation screening of standard hydrophilic and hydrophobic prototype gelatins and also for mucoadhesive thiomers.
- Subjects
POLYMERS; NANOPARTICLES; FIELD-flow fractionation; PROTEINS; GELATIN; BIODEGRADATION of pharmaceutical drug carriers; MOLECULAR weights; TUMOR treatment
- Publication
LC-GC Europe, 2009, Vol 22, Issue 8, p390
- ISSN
1471-6577
- Publication type
Article