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- Title
Phytochemicals, cytotoxicity, and genotoxicity of three Artocarpus species reveal arbutin in A. lacucha.
- Authors
Kowit Noikotr; Chaveerach, Arunrat; Sudmoon, Runglawan; Tawatchai Tanee; Natcha Patarapadungkit
- Abstract
Leaves of three Artocarpus species were hexane and ethanol extracted and chemically analysed. Cytotoxicity and genotoxicity tests were performed on peripheral blood mononuclear cells. The main phytochemical in the hexane extracts was (Z)-9-octadecenamide (oleamide). The ethanol extracts showed 21% 9,19-cyclolanost-24-en-3-ol in A. altilis, 19% n-hexadecanoic acid in A. heterophyllus, and 21% arbutin in A. lacucha. The hexane extract of A. altilis gave an IC50 of 0.00035 mg/ml but no IC50 values for A. heterophyllus and A. lacucha extracts. Ethanol extracts of A. altilis and A. lacucha had IC50 values of 0.868 and 0.218 mg/ml, respectively, but none for A. heterophyllus. All the hexane extracts showed non-significant DNA damage, while all the ethanol extracts significantly induced DNA damage (p < 0.05). A. lacucha leaf is newly reported as an alternative source of arbutin.
- Subjects
ARTOCARPUS; PHYTOCHEMICALS; CELL-mediated cytotoxicity; PLANT species; GENETIC toxicology
- Publication
ScienceAsia, 2018, Vol 44, Issue 3, p170
- ISSN
1513-1874
- Publication type
Article
- DOI
10.2306/scienceasia1513-1874.2018.44.170