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- Title
Acitretin treatment for hidradenitis suppurativa: a prospective series of 17 patients.
- Authors
Matusiak, Ł.; Bieniek, A.; Szepietowski, J.C.
- Abstract
Background The management of hidradenitis suppurativa ( HS) is still challenging, and new treatment methods are necessary. Acitretin seems to be a promising agent in HS management; however, literature data are limited. Objectives To investigate the clinical efficacy of acitretin monotherapy in 17 patients with long-standing and recalcitrant HS. Simultaneously, an assessment of quality of life was carried out. Methods The study was conducted with a group of 17 patients with HS. Patients were treated with acitretin for up to 9 months and examined at baseline, after 1 month, and then every 3 months from baseline. The clinical extent of disease severity was measured with the HS Severity Index ( HSSI), Hurley scoring system, Physician's Global Assessment and Dermatology Life Quality Index ( DLQI). Results Nine patients (53%) finished the whole 9 months of acitretin treatment. The mean acitretin dose was 0·56 ± 0·08 mg kg−1 daily. A significant improvement of clinical manifestation ( HSSI, DLQI) was observed after only 1 month of therapy, and further improvement was recorded during the next few months. Overall, eight subjects (47%) fulfilled the criteria for response (HSSI ≥ 50% reduction from baseline). The dropout rate was 47%, due mostly to drug ineffectiveness and adverse events. Discontinuation of treatment resulted in deterioration or relapse of HS 2-8 months after acitretin cessation, in all but one patient. Conclusions HS treatment with acitretin seems to be a promising method of disease management. However, due to the high daily dosage, its usage may be limited.
- Subjects
HIDRADENITIS; CHRONIC wounds &; injuries; SCHOOL dropouts; QUALITY of life; DISEASES -- Management
- Publication
British Journal of Dermatology, 2014, Vol 171, Issue 1, p170
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/bjd.12884