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- Title
Effect of Quercetin on RAC1 Gene Expression as a Marker of Metastasis in Cervical Cancer Cells.
- Authors
Chakerzehi, Arezu; Arvanagh, Neda Eivazi; Saedi, Samaneh; Hematti, Mahdiyeh; Ardakani, Javad Mohiti; Moradi, Ali; Shokouhi, Abolfazl
- Abstract
Background: Cancer metastasis is the most important cause of cancer death and different treatment strategies have targeted on preventing the occurrence of metastasis. Quercetin is a flavonoid and widely used as an antioxidant and recent studies have discovered its anticancer and antiproliferative capabilities. Rac1 is protein known to involve in tumor invasion and metastases. Objectives: In this study, we investigated the effect of quercetin on expression of Rac1 protein. Materials and Methods: In this experimental study, HeLa cells were treated with quercetin at 2 concentrations (20 and 40 µM) for 24 hours and then cell lysate was assessed by Western blotting analysis to investigate the impact of quercetin on expression of Rac1 protein. Results: Quercetin significantly decreased Rac1 expression of HeLa cells assessed by western blotting, in dose-dependent manners (P < 0.05). Conclusions: This study showed that quercetin decreased Rac1 expression as a marker of metastasis in cervical cancer cells. Therefore, the quercetin may provide an effective new strategy to reduce of tumor metastasis. Conclusions: This study showed that quercetin decreased Rac1 expression as a marker of metastasis in cervical cancer cells. Therefore, the quercetin may provide an effective new strategy to reduce of tumor metastasis.
- Subjects
QUERCETIN; GENE expression; METASTASIS; CERVICAL cancer; CANCER cells; GENETICS
- Publication
Zahedan Journal of Research in Medical Sciences, 2015, Vol 17, Issue 5, p1
- ISSN
2008-7977
- Publication type
Article
- DOI
10.17795/zjrms962