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- Title
Higher Motility Enhances Bacterial Density and Inflammatory Response in Dyspeptic Patients Infected with Helicobacter pylori.
- Authors
Kao, Cheng-Yen; Sheu, Bor-Shyang; Sheu, Shew-Meei; Yang, Hsiao-Bai; Chang, Wei-Lun; Cheng, Hsiu-Chi; Wu, Jiunn-Jong
- Abstract
Background Motility mediated by the flagella of Helicobacter pylori is important for the cells to move toward the gastric mucus in niches adjacent to the epithelium; then, H. pylori uses the adhesin SabA to interact with sialyl-Lex on inflammatory host cells for persistent infection. Here, we reveal the clinical association of bacterial motility, SabA expression, and pathological outcomes. Methods Ninety-six clinical isolates were screened for bacterial motility, and the expression of SabA of each isolate was confirmed by Western blotting. H. pylori-infected patients were assessed for their bacterial density, sialyl-Lex expression, inflammatory scores, and clinical diseases. Results The mean diameter in the motility assay was 17 mm, and eight (8.3%) of the strains had impaired motility, with a diameter <5 mm. H. pylori density in cardia, the acute inflammatory score in the body locus, and the prevalence rate of gastric atrophy were increased in patients infected with higher-motility strains ( p = .023, <.001, or <.001, respectively). The total inflammatory scores (both acute and chronic) and bacterial density dramatically increased in patients expressing the sialyl-Lex antigen and infected with higher-motility, SabA-positive H. pylori ( p = .016, .01, or .005, respectively). Conclusion These results suggest that the higher motility of H. pylori enhances pathological outcomes, and the SabA-sialyl-Lex interaction has a synergistic effect on virulence of the higher-motility strains.
- Subjects
HELICOBACTER pylori infections; INDIGESTION; GASTRIC mucosa; MOTILITY of bacteria; ATROPHY; PATIENTS
- Publication
Helicobacter, 2012, Vol 17, Issue 6, p411
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1111/j.1523-5378.2012.00974.x