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- Title
Proton pump inhibitors reduce breast cancer risk in gastric ulcer patients: A population‐based cohort study.
- Authors
Ding, Dah‐Ching; Sung, Fung‐Chang; Chen, Weishan; Wang, Jen‐Hung; Lin, Shinn‐Zong
- Abstract
We aim to evaluate breast cancer risk relating to PPIs usage in women with peptic ulcer. From 2000 to 2013, incidence rates of breast cancer were compared between the two cohorts (with or without PPIs). Each study cohort consisted of 4838 women. The incidence density rate of breast cancer in the PPI cohort was 0.29 that in the comparison cohort (10.0 vs 31.6 per 10 000 person‐years), with an adjusted HR (hazard ratio) of 0.32 (95% CI = 0.20‐0.49) for the PPI cohort. In conclusion, the medication of PPIs is associated with reduced breast cancer risk for women with gastric ulcer.
- Subjects
BREAST tumor risk factors; BREAST tumors; CONFIDENCE intervals; LONGITUDINAL method; PEPTIC ulcer; PROTON pump inhibitors; RETROSPECTIVE studies; DESCRIPTIVE statistics; ODDS ratio
- Publication
Breast Journal, 2020, Vol 26, Issue 3, p474
- ISSN
1075-122X
- Publication type
Article
- DOI
10.1111/tbj.13519