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- Title
Hematopoietic stem cell transplantation for adults with acute promyelocytic leukemia in the ATRA era: a survey of the European Cooperative Group for Blood and Marrow Transplantation.
- Authors
Sanz, M. A.; Labopin, M.; Gorin, N.-C.; de la Rubia, J.; Arcese, W.; Meloni, G.; Bacigalupo, A.; Alessandrino, P.; Carreras, E.; Iriondo, A.; Novitzky, N.; Jacobs, P.; Bandini, G.; Lo-Coco, F.; Frassoni, F.; Rocha, V.
- Abstract
We performed a survey of the European Cooperative Group for Blood and Marrow Transplantation to analyze the outcome of 625 acute promyelocytic leukemia (APL) patients transplanted with auto- or allogeneic-hematopoietic stem cell transplantation (autoHSCT, alloHSCT) after 1993, in first (CR1) or in second complete remission (CR2). Leukemia-free survival (LFS) at 5 years in CR1 was 69% for 149 patients autografted and 68% for 144 patients allografted, whereas in CR2, LFS was 51% in 195 autoHSCT and 59% in 137 alloHSCT recipients, respectively. In the group of autoHSCT for CR1 (n=149), higher relapse incidence (RI) was associated with shorter time from diagnosis to transplant (<7.6 months); transplant-related mortality (TRM) was increased in older patients (>47 years), whereas for CR2, longer time from diagnosis to transplant (>18 months) was associated with increased LFS and decreased RI. In the alloHSCT group for CR1 (n=144), age (<33 years) was associated with increased LFS and decreased TRM and for CR2 (n=137), the use of mobilized peripheral blood stem cells was associated with decreased TRM. Female recipient, a female donor to male recipient and transplants performed before 1997 were associated with decreased RI. In conclusion, HSCT still appears to have a role in APL, especially for patients in CR2.Bone Marrow Transplantation (2007) 39, 461–469. doi:10.1038/sj.bmt.1705620; published online 26 February 2007
- Subjects
EUROPE; STEM cell transplantation; MYELOID leukemia; BONE marrow transplantation; MORTALITY
- Publication
Bone Marrow Transplantation, 2007, Vol 39, Issue 8, p461
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705620