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- Title
A Controlled Clinical Trial of Nicotinohydroxamic Acid and Neomycin in Advanced Chronic Liver Disease.
- Authors
Hirayama, Chisato; Ichida, Fumihiro; Takahashi, Yoshiyata; Koizumi, Takeo; Sato, Shunichi; Kosaka, Yoshitane; Wakui, Kazuo; Shimada, Yoshihiro; Yoshiba, Akira; Hattori, Nobu; Ooya, Takahiko; Takino, Tatsuo; Takeda, Hakushi
- Abstract
In a double-blind clinical trial, 24 patients with advanced chronic liver disease received 1.2 g of nicotinohydroxamic acid daily and 23 patients received 1.5 g of neomycin. Patients receiving nicotinohydroxamic acid showed significant improvement in blood ammonia levels as compared to patients receiving neomycin. Nicotinohydroxamic acid induced some side effects, such as mild diarrhea, constipation and anorexia, but less than in cases of neomycin. Copyright © 1982 S. Karger AG, Basel
- Publication
Digestion, 1982, Vol 25, Issue 2, p115
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000198819