We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline—Results From the Lifebrain Consortium.
- Authors
Fjell, Anders M; Sørensen, Øystein; Amlien, Inge K; Bartrés-Faz, David; Brandmaier, Andreas M; Buchmann, Nikolaus; Demuth, Ilja; Drevon, Christian A; Düzel, Sandra; Ebmeier, Klaus P; Ghisletta, Paolo; Idland, Ane-Victoria; Kietzmann, Tim C; Kievit, Rogier A; Kühn, Simone; Lindenberger, Ulman; Magnussen, Fredrik; Macià, Didac; Mowinckel, Athanasia M; Nyberg, Lars
- Abstract
We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. "PSQI # 1 Subjective sleep quality" and "PSQI #5 Sleep disturbances" were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with "PSQI #5 Sleep disturbances" emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.
- Publication
Cerebral Cortex, 2021, Vol 31, Issue 4, p1953
- ISSN
1047-3211
- Publication type
Article
- DOI
10.1093/cercor/bhaa332