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- Title
Bidirectional Modulation of Numerical Magnitude.
- Authors
Arshad, Qadeer; Nigmatullina, Yuliya; Nigmatullin, Ramil; Asavarut, Paladd; Goga, Usman; Khan, Sarah; Sander, Kaija; Siddiqui, Shuaib; Roberts, R. E.; Kadosh, Roi Cohen; Bronstein, Adolfo M.; Malhotra, Paresh A.
- Abstract
Numerical cognition is critical for modern life; however, the precise neural mechanisms underpinning numerical magnitude allocation in humans remain obscure. Based upon previous reports demonstrating the close behavioral and neuro-anatomical relationship between number allocation and spatial attention, we hypothesized that these systems would be subject to similar controlmechanisms, namely dynamic interhemispheric competition. We employed a physiological paradigm, combining visual and vestibular stimulation, to induce interhemispheric conflict and subsequent unihemispheric inhibition, as confirmed by transcranial direct current stimulation (tDCS). This allowed us to demonstrate the first systematic bidirectional modulation of numericalmagnitude toward either higher or lower numbers, independently of either eye movements or spatial attention mediated biases. We incorporated both our findings and those fromthemostwidely accepted theoretical framework for numerical cognition to present a novel unifying computational model that describes how numerical magnitude allocation is subject to dynamic interhemispheric competition. That is, numerical allocation is continually updated in a contextualmanner based upon relativemagnitude, with the right hemisphere responsible for smallermagnitudes and the left hemisphere for largermagnitudes.
- Publication
Cerebral Cortex, 2016, Vol 26, Issue 5, p2311
- ISSN
1047-3211
- Publication type
Article
- DOI
10.1093/cercor/bhv344