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- Title
Thyroid Dysfunction - Risk of Fracture.
- Authors
Kanwar, Gulab; Shekhawat, Monika; Gondane, Ashwin; Sharma, Nidhi; Hada, Rinki; Chandel, Chandrajeet Singh
- Abstract
Thyroid diseases are common worldwide. India too carries a significant burden of the same. Thyroid dysfunctions are more commonly seen in females and the incidence increases with age. These mainly affect musculoskeletal system, cardiovascular system and nervous system. Variations in levels of TSH are significantly associated with risk of fracture. The study was conducted in Department of Biochemistry and Orthopaedics, Govt. Medical College, Kota and attached group of hospitals. Duration of study is from September 2014 to May 2015. Level of Thyroid Stimulating Hormone (TSH) was measured. A total of 177 fractured patients of ages between 25 - 50 years of both sexes were included in the study. The estimation of TSH was done by chemiluminescence in Hormonal Assay Lab, Department of Biochemistry, Govt. Medical College, Kota, Rajasthan, India. Among the total 177 fractured patients, we found 8 hyperthyroid (< 0.05mU/L), 12 subclinical hyperthyroid (0.05-0.3mU/L), 5 hypothyroid (>10mU/L), 16 subclinical hypothyroid (4.5- 10mU/L) and 136 euthyroid patients (0.3-4.5mU/L). Analysis was done by Microsoft Excel. Mean ± SD of TSH was calculated in all cases. The results were compared by one - way ANOVA between hyperthyroid, subclinical hyperthyroid, hypothyroid, subclinical hypothyroid and euthyroid cases. P value was found to be < 0.05, which is highly significant. Our study shows that the any variations in level of TSH from the normal range, is a risk of fracture.
- Subjects
RISK factors of fractures; THYROID diseases; HYPERTHYROIDISM
- Publication
International Journal of Pure & Applied Sciences & Technology, 2015, Vol 30, Issue 1, p18
- ISSN
2229-6107
- Publication type
Article