We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Use of miRNAs as Biomarkers in Sepsis.
- Authors
Dumache, Raluca; Dumbuleu, Corina Maria; Bedreag, Ovidiu Horea; Papurica, Marius; Sandesc, Dorel; Rogobete, Alexandru Florin; Nartita, Radu; Sarandan, Mirela; Cradigati, Alina Carmen
- Abstract
Sepsis is one of the most common causes of death in critical patients. Severe generalized inflammation, infections, and severe physiological imbalances significantly decrease the survival rate with more than 50%. Moreover, monitoring, evaluation, and therapy management often become extremely difficult for the clinician in this type of patients. Current methods of diagnosing sepsis vary based especially on the determination of biochemical-humoral markers, such as cytokines, components of the complement, and proinflammatory and anti-inflammatory compounds. Recent studies highlight the use of new biomarkers for sepsis, namely, miRNAs. miRNAs belong to a class of small, noncoding RNAs with an approximate content of 19-23 nucleotides. Following biochemical and physiological imbalances, the expression of miRNAs in blood or other body fluids changes significantly. Moreover, its stability, specificity, and selectivity make miRNAs ideal candidates for sepsis biomarkers. In conclusion, we can affirm that stable species of circulating miRNAs represent potential biomarkers for monitoring the evolution of sepsis.
- Subjects
MICRORNA; BIOLOGICAL tags; SEPSIS; INFECTION; INFLAMMATION
- Publication
Analytical Cellular Pathology: Cellular Oncology, 2015, Vol 2015, p1
- ISSN
2210-7177
- Publication type
Article
- DOI
10.1155/2015/186716