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- Title
The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis.
- Authors
Olmedo-Nieva, Leslie; Muñoz-Bello, J. Omar; Contreras-Paredes, Adriana; Lizano, Marcela
- Abstract
Persistent infections with High Risk Human Papillomaviruses (HR-HPVs) are the main cause of cervical cancer development. The E6 and E7 oncoproteins of HR-HPVs are derived from a polycistronic pre-mRNA transcribed from an HPV early promoter. Through alternative splicing, this pre-mRNA produces a variety of E6 spliced transcripts termed E6*. In pre-malignant lesions and HPV-related cancers, different E6/E6* transcriptional patterns have been found, although they have not been clearly associated to cancer development. Moreover, there is a controversy about the participation of E6* proteins in cancer progression. This review addresses the regulation of E6 splicing and the different functions that have been found for E6* proteins, as well as their possible role in HPV-induced carcinogenesis.
- Subjects
PAPILLOMAVIRUS diseases; CERVICAL cancer; CARCINOGENESIS; RNA splicing; SPLICEOSOMES
- Publication
Viruses (1999-4915), 2018, Vol 10, Issue 1, p45
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v10010045