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- Title
Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways.
- Authors
Ullmer, Wendy; Semler, Bert L.
- Abstract
To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from the antiviral response. Members of the Picornaviridae family of small RNA viruses have evolved numerous diverse strategies to evade RNA decay, including incorporation of stabilizing elements into vRNA and re-purposing host stability factors. Viral proteins are deployed to disrupt and inhibit components of the decay machinery and to redirect decay machinery to the advantage of the virus. This review summarizes documented interactions of picornaviruses with cellular RNA decay pathways and processes.
- Subjects
PICORNAVIRUSES; RIBOSOMAL DNA; PICORNAVIRALES; PICORNAVIRUS infections; RHINOVIRUSES; THERAPEUTICS
- Publication
Viruses (1999-4915), 2016, Vol 8, Issue 12, p335
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v8120335