We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Uncovering Viral Protein-Protein Interactions and their Role in Arenavirus Life Cycle.
- Authors
Loureiro, Maria Eugenia; D'Antuono, Alejandra; Levingston Macleod, Jesica M.; López, Nora
- Abstract
The Arenaviridae family includes widely distributed pathogens that cause severe hemorrhagic fever in humans. Replication and packaging of their single-stranded RNA genome involve RNA recognition by viral proteins and a number of key protein-protein interactions. Viral RNA synthesis is directed by the virus-encoded RNA dependent-RNA polymerase (L protein) and requires viral RNA encapsidation by the Nucleoprotein. In addition to the role that the interaction between L and the Nucleoprotein may have in the replication process, polymerase activity appears to be modulated by the association between L and the small multifunctional Z protein. Z is also a structural component of the virions that plays an essential role in viral morphogenesis. Indeed, interaction of the Z protein with the Nucleoprotein is critical for genome packaging. Furthermore, current evidence suggests that binding between Z and the viral envelope glycoprotein complex is required for virion infectivity, and that Z homo-oligomerization is an essential step for particle assembly and budding. Efforts to understand the molecular basis of arenavirus life cycle have revealed important details on these viral protein-protein interactions that will be reviewed in this article.
- Subjects
ARENAVIRUS diseases; HEMORRHAGIC fever; RNA synthesis; RNA polymerases; VIRAL envelopes
- Publication
Viruses (1999-4915), 2012, Vol 4, Issue 9, p1651
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v4091651