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- Title
Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma.
- Authors
SEI UEDA; MITSURO KANDA; YUSUKE SATO; HAYATO BABA; SHUNSUKE NAKAMURA; KOICHI SAWAKI; DAI SHIMIZU; SATORU MOTOYAMA; TSUTOMU FUJII; YASUHIRO KODERA; SHUJI NOMOTO
- Abstract
Background/Aim: To investigate the function of chromobox 2 (CBX2) in oesophageal squamous cell carcinoma (OSCC). Materials and Methods: We used real-time quantitative reverse transcription PCR (qRT-PCR) and immunohisto - chemistry to determine CBX2 expression levels in 13 human OSCC cell lines and clinical specimens of two independent cohorts of patients with OSCC. Results: PCR array analysis revealed that CBX2 was co-ordinately expressed with WNT5B in OSCC cell lines. RT-qPCR analysis of clinical samples revealed a high tumour-specific CBX2 expression compared with normal oesophageal tissues. High CBX2 expression was significantly associated with shorter disease-specific survival, hematogenous recurrence, and overall recurrence. Analysis of tissue microarrays of one cohort revealed that patients with higher CBX2 levels tended to have a shorter disease-specific survival. Conclusion: CBX2 overexpression in OSCC tissues may serve as a novel biomarker for predicting survival and hematogenous recurrence.
- Subjects
SQUAMOUS cell carcinoma; CELL lines; TISSUE analysis; PROGNOSIS
- Publication
Cancer Genomics & Proteomics (1109-6535), 2020, Vol 17, Issue 4, p391
- ISSN
1109-6535
- Publication type
Article
- DOI
10.21873/cgp.20198