We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Phenylalanine-arginine ß-naphthylamide could enhance neomycin-sensitivity on Riemerella anatipestifer in vitro and in vivo.
- Authors
Shiqi Liu; Junfa Liu; Ning Fu; Kornmatitsuk, Bunlue; Zhuanqiang Yan; Junrong Luo
- Abstract
Riemerella anatipestifer is an important duck pathogen responsible for septicemia and infectious serositis, which has caused great economic losses to the duck industry. Phenylalanine-arginine ß-naphthylamide (PAßN) is an efflux pump inhibitor, which mainly reduces the efflux effect by competing with antibiotics for efflux pump channels. Here, we found that R. anatipestifer strain GD2019 showed resistances to gentamicin, amikacin, kanamycin, and neomycin. Notably, PAßN could significantly reduce the Minimal inhibitory concentrations (MICs) of neomycin on the GD2019 strain. Moreover, PAßN combined with neomycin significantly decreased bacterial loads, relieved pathological injury and increase survival rate (p < 0.05) for the ducks lethally challenged by the GD2019 strain. Therefore, our results suggested, in vitro and in vivo, PAßN could reduce neomycin-resistant of R. anatipestifer. Importantly, finding of this study provide a new approach for treating antibiotic-resistant R. anatipestifer infection.
- Subjects
NEOMYCIN; KANAMYCIN; SURVIVAL rate; SEPSIS; ANTIBIOTICS; ARGININE; AMIKACIN
- Publication
Frontiers in Microbiology, 2023, Vol 13, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2022.985789