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- Title
Acquired CNS Demyelinating Syndrome in Children Referred to Shiraz Pediatric Neurology Ward.
- Authors
INALOO, Soroor; HAGHBIN, Saeedeh; MORADI, Mehrpoor; DASHTI, Hassan; SAFARI, Nazila
- Abstract
Objective Incidence of CNS acquired demyelinating syndrome (ADS), especially multiple sclerosis (MS) in children, appears to be on the rise worldwide. The objective of this study was to determine prevalence, clinical presentation, neuroimaging features, and prognosis of different types of ADS in Iranian children. Materials & Methods During the period 2002-2012, all the patients (aged 1-18 years) with ADS, such as MS, acute disseminated encephalomyelitis (ADEM), optic neurotic (ON), Devic disease, and transverse myelitis (TM), referred to the pediatric neurology ward, Nemazee Hospital, Shiraz University of Medical Sciences, were included in this study. Demographic data, clinical signs and symptoms, past and family history, preclinical findings, clinical course, and outcome were obtained. Results We identified 88 patients with ADS in our center. The most prevalent disease was MS with 36.5% (n=32), followed by AEDM 26.1% (n=31), ON 17% (n=13), TM 15.9% (n=14), and Devic disease 4.5% (n=4). MS, ON, TM were more common among females while ADEM was more common in males. Children with ADEM were significantly younger than those with other types of ADS. Family history was positive in 10% of patients with MS. Previous history of recent infection was considerably seen in cases with ADEM. Clinical presentation and prognosis in this study was in accordance with those in previous studies on children. Conclusion In this study, the most common type of ADS was MS, which was more common in female and older age cases. ADEM was more common in male and younger children. ADEM and ON had the best and Devic disease had the worst prognosis.
- Subjects
IRAN; LONGITUDINAL method; PROBABILITY theory; QUESTIONNAIRES; SEX distribution; STATISTICS; DATA analysis; CROSS-sectional method; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; HEREDITARY central nervous system demyelinating diseases; MANN Whitney U Test; SYMPTOMS; PROGNOSIS
- Publication
Iranian Journal of Child Neurology, 2014, Vol 8, Issue 2, p18
- ISSN
1735-4668
- Publication type
Article