We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer.
- Authors
Gu, Juanjuan; Polley, Eric C.; Denis, Max; Carter, Jodi M.; Pruthi, Sandhya; Gregory, Adriana V.; Boughey, Judy C.; Fazzio, Robert T.; Fatemi, Mostafa; Alizad, Azra
- Abstract
<bold>Background: </bold>Early prediction of tumor response to neoadjuvant chemotherapy (NACT) is crucial for optimal treatment and improved outcome in breast cancer patients. The purpose of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to NACT in patients with invasive breast cancer.<bold>Methods: </bold>In a prospective study, 62 patients with biopsy-proven invasive breast cancer were enrolled. Three SWE studies were conducted on each patient: before, at mid-course, and after NACT but before surgery. A new parameter, mass characteristic frequency (fmass), along with SWE measurements and mass size was obtained from each SWE study visit. The clinical biomarkers were acquired from the pre-NACT core-needle biopsy. The efficacy of different models, generated with the leave-one-out cross-validation, in predicting response to NACT was shown by the area under the receiver operating characteristic curve and the corresponding sensitivity and specificity.<bold>Results: </bold>A significant difference was found for SWE parameters measured before, at mid-course, and after NACT between the responders and non-responders. The combination of Emean2 and mass size (s2) gave an AUC of 0.75 (0.95 CI 0.62-0.88). For the ER+ tumors, the combination of Emean_ratio1, s1, and Ki-67 index gave an improved AUC of 0.84 (0.95 CI 0.65-0.96). For responders, fmass was significantly higher during the third visit.<bold>Conclusions: </bold>Our study findings highlight the value of SWE estimation in the mid-course of NACT for the early prediction of treatment response. For ER+ tumors, the addition of Ki-67improves the predictive power of SWE. Moreover, fmass is presented as a new marker in predicting the endpoint of NACT in responders.
- Subjects
CANCER invasiveness; NEOADJUVANT chemotherapy; SHEAR waves; BREAST cancer; RECEIVER operating characteristic curves; ACOUSTIC radiation force impulse imaging; CORE needle biopsy; CANCER relapse
- Publication
Breast Cancer Research, 2021, Vol 23, Issue 1, p1
- ISSN
1465-5411
- Publication type
journal article
- DOI
10.1186/s13058-021-01429-4