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- Title
Green extraction and biological activity of phenolic extracts from cashew nut testa using a combination of enzyme and ultrasound‐assisted treatments.
- Authors
Van Thanh, Hoang; Phi, Nguyen Thi Lan; Khoi, Nguyen Tien; Hoan, Nguyen Xuan; Van Hung, Pham
- Abstract
BACKGROUND: A combination of enzymes and ultrasound treatment was employed to extract bioactive compounds from cashew nut testa, a by‐product of the food industry. The total catechin, flavonoid, and phenolic content of extracts was investigated together with their biological activity. RESULTS: Enzyme and ultrasound‐assisted extraction (E‐UAE) was performed by incubation with Viscozyme L (20 mL kg−1 of testa powder, v/w) for 60 min before sonication for 40 min. Ultrasound and enzyme‐assisted extraction (U‐EAE) was carried out using sonication for 40 min before incubation with Viscozyme L (20 mL kg−1 of testa powder) for 60 min. Under appropriate conditions, the total phenolic, flavonoid, catechin, and epigallocatechin gallate content of the extracts from cashew nut testa obtained from a combination method (U‐EAE or E‐UAE) was significantly higher than that obtained using a single method (EAE or UAE). Extracts of cashew nut testa obtained from E‐UAE displayed significantly higher antioxidant and α‐amylase inhibitory activity than those from the U‐EAE. The E‐UAE extract at a concentration of 100 μg mL−1 had a greater impact on the cell viability of MCF‐7 after treatment (22% cell viability) than did the doxorubicin (DOX) at 4 μg mL−1 (39% cell viability), and the E‐UAE extract at 100 μg mL−1 was considered to be safe for healthy cells because the viability of the bovine aerotic endothelial cells treated with this extract was 91%, which was similar to the DOX treatment. CONCLUSION: The extract of cashew nut testa obtained from E‐UAE is valuable and promising for the development of anti‐inflammatory therapeutic drugs. © 2023 Society of Chemical Industry.
- Subjects
SOCIETY of Chemical Industry (Great Britain); CASHEW nuts; DOXORUBICIN; CATECHIN; EPIGALLOCATECHIN gallate; FLAVONOIDS; EXTRACTS; CELL survival
- Publication
Journal of the Science of Food & Agriculture, 2023, Vol 103, Issue 11, p5626
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.12641