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- Title
Cyclosporine-responsive thrombocytopenia in a patient with chloramphenicol-associated myelodysplastic syndrome.
- Authors
Arber, Caroline; Buser, Andreas; Heim, Dominik; Gratwohl, Alois; Tichelli, Andr; Passweg, Jakob R.
- Abstract
A 64-yr-old patient with myelodysplastic syndrome (MDS), with refractory cytopenia with multilineage dysplasia subtype following chloramphenicol exposure received immunosuppressive treatment with antithymocyte globulin and cyclosporine (CsA). Complete remission was achieved and CsA was tapered after 2.5 yr. Shortly after CsA withdrawal, the patient relapsed with thrombocytopenia but responded to restoration of CsA. This case illustrates that immune-mediated mechanisms of cytopenia in MDS may be dependent on continued immunosuppressive treatment similar to aplastic anemia.
- Subjects
THROMBOCYTOPENIA; BLOOD platelet disorders; IMMUNOSUPPRESSIVE agents; APLASTIC anemia; BLOOD diseases; DYSPLASIA; ANEMIA; CELL transformation
- Publication
European Journal of Haematology, 2006, Vol 76, Issue 3, p255
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/j.0902-4441.2005.00593.x