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- Title
Regulation of Neuronal Differentiation by Retinoic Acid Alone and in Cooperation with Thyroid Hormone or Hydrocortisone.
- Authors
Ved, H.S.; Pieringer, Ronald A.
- Abstract
Cultures highly enriched in neurons obtained from embryonic mouse cerebra were used to demonstrate that: (1) at the optimum concentration of 10-8M retinoic acid stimulated the neurons to produce axon- and dentrite-like structures as determined by phase contrast and fluorescent microscopy; (2) the same concentration of retinoic acid stimulated acetyl cholinesterase and choline acetyltransferase activities; (3) treatment of neurons of either prenatal or neonatal equivalent age with retinoic acid produced a sustained stimulation of neuronal differentiation, and (4) retinoic acid cooperatively stimulated neuronal differentiation with either thyroid hormone or hydrocortisone. Copyright © 1993 S. Karger AG, Basel
- Publication
Developmental Neuroscience, 1993, Vol 15, Issue 1, p49
- ISSN
0378-5866
- Publication type
Article
- DOI
10.1159/000111316