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- Title
Transient and Persistent Pain Induced Connectivity Alterations in Pediatric Complex Regional Pain Syndrome.
- Authors
Linnman, Clas; Becerra, Lino; Lebel, Alyssa; Berde, Charles; Grant, P. Ellen; Borsook, David
- Abstract
Evaluation of pain-induced changes in functional connectivity was performed in pediatric complex regional pain syndrome (CRPS) patients. High field functional magnetic resonance imaging was done in the symptomatic painful state and at follow up in the asymptomatic pain free/recovered state. Two types of connectivity alterations were defined: (1) Transient increases in functional connectivity that identified regions with increased cold-induced functional connectivity in the affected limb vs. unaffected limb in the CRPS state, but with normalized connectivity patterns in the recovered state; and (2) Persistent increases in functional connectivity that identified regions with increased cold-induced functional connectivity in the affected limb as compared to the unaffected limb that persisted also in the recovered state (recovered affected limb versus recovered unaffected limb). The data support the notion that even after symptomatic recovery, alterations in brain systems persist, particularly in amygdala and basal ganglia systems. Connectivity analysis may provide a measure of temporal normalization of different circuits/regions when evaluating therapeutic interventions for this condition. The results add emphasis to the importance of early recognition and management in improving outcome of pediatric CRPS.
- Subjects
COMPLEX regional pain syndromes; CHRONIC pain; FUNCTIONAL magnetic resonance imaging; FOLLOW-up studies (Medicine); BRAIN imaging; PUBLIC health; NEUROLOGICAL disorders
- Publication
PLoS ONE, 2013, Vol 8, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0057205