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- Title
Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1β.
- Authors
Liesa, Marc; Borda-d'Água, Bárbara; Medina-Gómez, Gema; Lelliott, Christopher J.; Paz, José Carlos; Rojo, Manuel; Palacín, Manuel; Vidal-Puig, Antonio; Zorzano, Antonio
- Abstract
Background: There is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression. Methodology/Principal Findings: Here, we demonstrate that reduced mitochondrial size observed in knock-out mice for the transcriptional regulator PGC-1β is associated with a selective reduction in Mitofusin 2 (Mfn2) expression, a mitochondrial fusion protein. This decrease in Mfn2 is specific since expression of the remaining components of mitochondrial fusion and fission machinery were not affected. Furthermore, PGC-1β increases mitochondrial fusion and elongates mitochondrial tubules. This PGC-1β-induced elongation specifically requires Mfn2 as this process is absent in Mfn2-ablated cells. Finally, we show that PGC-1β increases Mfn2 promoter activity and transcription by coactivating the nuclear receptor Estrogen Related Receptor α (ERRα). Conclusions/Significance: Taken together, our data reveal a novel mechanism by which mammalian cells control mitochondrial fusion. In addition, we describe a novel role of PGC-1β in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2.
- Subjects
GENETIC regulation; GENETIC transcription; GENE expression; NUCLEAR receptors (Biochemistry); SELECTIVE reduction (Multiple pregnancy); ESTROGEN receptors; MITOCHONDRIAL dynamics; MITOCHONDRIAL DNA; MOLECULAR genetics
- Publication
PLoS ONE, 2008, Vol 3, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0003613