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- Title
Betulinic Acid from Zizyphus Joazeiro Bark Using Focused Microwave-Assisted Extraction and Response Surface Methodology.
- Authors
Sousa Fonseca, Fernanda Carolina; Batista Reis, Letícia Caribé; dos Santos, Jener David Gonçalves; Cardoso Branco, Carla Rodrigues; da Costa Ferreira, Sergio Luis; Mauricio David, Jorge; Branco, Alexsandro
- Abstract
Background: The effect of the extraction time (min) and temperature (°C) on the yield of betulinic acid (BA) from Zizyphus joazeiro barks using focused microwave-assisted extraction was investigated. Materials and Methods: The ethyl acetate was used as extractor solvent because it was shown to provide a betulinic acid-clean extract. A full two-level statistical factorial design was applied to determine the important effects and interactions of these independent variables upon the yield of BA. Results: The conditions that produced the highest yield of BA were at temperature of 70 °C and an extraction time of 15 min (3.33 mg per gram of plant). Conclusion: The BA has drawn attention due to its use as a raw material in the synthesis of active compounds against the Human Immunodeficiency Virus (HIV).
- Subjects
ZIZIPHUS joazeiro; BARK; ACIDS; WOODY plant anatomy; CHEMISTRY
- Publication
Pharmacognosy Magazine, 2017, Vol 13, Issue 50, p226
- ISSN
0973-1296
- Publication type
Article
- DOI
10.4103/0973-1296.204565