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- Title
Recent advances in total synthesis of natural products by masked ortho‐benzoquinones.
- Authors
Chen, Chih‐Ming; Hsieh, Hsing‐Pang
- Abstract
The Diels‐Alder adducts of masked ortho‐benzoquinone (MOB) normally perform high regio‐ and stereoselectivity and are generated under mild conditions. The advantages of MOB include: (a) Containing highly functional moieties: alkene, diene, carbonyl, enone, and dienone; (b) Easily accessible from 2‐methoxyphenol derivatives via oxidative dearomatization, and related 2‐methoxyphenol easily prepared from commercially available starting materials; (c) The Diels‐Alder adducts possessing unique features such as regio‐ and stereoselectivity and at least four contiguous stereogenic centers in one step. Furthermore, related bicyclo[2.2.2]octenone skeleton can be applied to further complex structure construction by various chemical transformations, such as radical cyclization, oxa‐di‐π‐methane rearrangement, Beckwith‐Dowd rearrangement, hydrogen atom transfer reaction, Cope rearrangement, Wanger‐Meerwein rearrangement, carbonyl‐ene reaction, aldol reaction, ring opening etc. Among these advantages, MOB system is prospected to continue as an important intermediate for total synthesis of natural products.
- Subjects
ATOM transfer reactions; ABSTRACTION reactions; NATURAL products; HYDROGEN transfer reactions; CHEMICAL amplification; QUINONE
- Publication
Journal of the Chinese Chemical Society, 2022, Vol 69, Issue 8, p1210
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.202200276