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- Title
Alpha-glucosidase inhibitors in the early treatment of type 2 diabetes.
- Authors
van de Laar, Floris Alexander
- Abstract
Alpha-glucosidase inhibitors (AGIs) are drugs that inhibit the absorption of carbohydrates from the gut and may be used in the treatment of patients with type 2 diabetes or impaired glucose tolerance. There is currently no evidence that AGIs are benefi cial to prevent or delay mortality or micro- or macrovascular complications in type 2 diabetes. Its benefi cial effects on glycated hemoglobin are comparable to metformin or thiazolidinediones, and probably slightly inferior to sulphonylurea. In view of the total body of evidence metformin seems to be superior to AGIs. More long-term studies are needed to study the effects of AGIs compared to other drugs. For patient with impaired glucose tolerance AGIs may prevent, delay or mask the occurrence of type 2 diabetes. A possible benefi cial effect on cardiovascular events should be confi rmed in new studies.
- Publication
Vascular Health & Risk Management, 2008, Vol 4, Issue 6, p1189
- ISSN
1176-6344
- Publication type
Article