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- Title
Children with asthma and eczema carrying filaggrin loss‐of‐function mutations have increased antibiotic use through to adulthood.
- Authors
Holden, Ciara; Soares, Patrícia; Fidler, Katy; Tavendale, Roger; Felton, Jessie; Mukhopadhyay, Somnath
- Abstract
Children with asthma and eczema who carry filaggrin (FLG) loss-of-function mutations are more likely to use antibiotics throughout childhood and early adulthood. The dysfunctional skin barrier caused by FLG mutations may contribute to increased bacterial entry, leading to a higher risk of bacterial infections and subsequent antibiotic use. This study, conducted in Scotland, analyzed data from 1,001 participants with asthma and found that those with FLG mutations had a greater incidence of antibiotic prescriptions, particularly for topical antibiotics. The findings suggest that personalized medicine approaches and education on bacterial infections may benefit this vulnerable population, while also emphasizing the importance of responsible antibiotic use to prevent antibiotic resistance.
- Subjects
ECZEMA; ASTHMA in children; URINARY tract infections; FILAGGRIN; ADULTS; MOLLUSCUM contagiosum; ANTIBIOTICS
- Publication
Clinical & Experimental Allergy, 2024, Vol 54, Issue 4, p291
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/cea.14440