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- Title
Effects of cultured keratinocyte‐ and fibroblast‐derived mediators on three‐dimensional skin models.
- Authors
Fonfara, Melina; Brodersen, Carina; Suhrkamp, Ina; Rodriguez, Elke; Weidinger, Stephan; Emmert, Hila
- Abstract
This article discusses the effects of keratinocyte- and fibroblast-derived factors on three-dimensional (3D) skin models, specifically focusing on epidermal organization and barrier marker expression. The study found that keratinocytes secrete pro-inflammatory mediators that can cause disease-associated patterns in the skin models. The researchers also observed that blocking IL-4Rα, a receptor involved in immune dysfunction, only partially improved the skin barrier, suggesting that other factors play a role in skin inflammation. Overall, the findings highlight the contribution of keratinocyte-derived cytokines to skin barrier dysfunction and the importance of understanding their role in conditions like atopic dermatitis.
- Subjects
THREE-dimensional modeling; SKIN proteins; CYTOSKELETAL proteins; PATHOLOGICAL physiology; ARYL hydrocarbon receptors
- Publication
Clinical & Experimental Allergy, 2024, Vol 54, Issue 1, p74
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/cea.14420