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- Title
Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks.
- Authors
Ovadia, Reuben; Mondielli, Clémence; Vasseur, Jean‐Jacques; Baraguey, Carine; Alvarez, Karine
- Abstract
We report a solution-phase synthesis of dimeric PNA-RNA (PNA = peptide nucleic acid) building blocks by using a microwave-assisted Ugi four-component reaction. A mixture of a functionalized amine, a carboxymethyl nucleobase, paraformaldehyde, and N4,2′- O,3′- O-tribenzoyl-5′-deoxy-5′-isocyanocytidine generates the dimeric chimeras in one step. The method is simple, and gives rapid access (5 min) to diversity, as exemplified by the products described here.
- Subjects
NUCLEOTIDE synthesis; NUCLEOSIDE synthesis; RIBONUCLEOSIDES; RNA; AMIDES
- Publication
European Journal of Organic Chemistry, 2017, Vol 2017, Issue 3, p469
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201601190