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- Title
One-Carbon Homologation of Primary Alcohols and the Reductive Homologation of Aldehydes Involving a Jocic-Type Reaction.
- Authors
Li, Zhexi; Gupta, Manoj K.; Snowden, Timothy S.
- Abstract
(Trichloromethyl)carbinols, which are formed in one operation from either alcohols or aldehydes, can be converted into primary alcohols in a Jocic-type reaction involving LiBH4. The net result is a convenient two-step, one-carbon homologation of primary alcohols or a reductive one-carbon homologation of aldehydes featuring a broad substrate scope. The method is step-economical, and it nicely complements established one-carbon homologation strategies.
- Subjects
TRICHLOROMETHYL group; METHANOL; CARBON analysis; ALDEHYDE analysis; PROTON transfer reactions; NUCLEOPHILES
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 32, p7009
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201501089