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- Title
Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus.
- Authors
González-Castillo, Celia; Ortuño-Sahagún, Daniel; Guzmán-Brambila, Carolina; Pallàs, Mercè; Rojas-Mayorquín, Argelia Esperanza
- Abstract
Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development. PTN is expressed in several tissues, where its signals are generally related with cell proliferation, growth, and differentiation by acting through different receptors. In Central Nervous System (CNS), PTN exerts post-developmental neurotrophic and -protective effects, and additionally has been involved in neurodegenerative diseases and neural disorders. Studies in Drosophila shed light on some aspects of the different levels of regulatory control of PTN invertebrate homologs. Specifically in hippocampus, recent evidence from PTN Knock-out (KO) mice involves PTN functioning in learning and memory. In this paper, we summarize, discuss, and contrast the most recent advances and results that lead to proposing a PTN as a neuromodulatory molecule in the CNS, particularly in hippocampus.
- Subjects
PLEIOTROPHIN; CENTRAL nervous system; HIPPOCAMPUS (Brain); EXTRACELLULAR matrix; CELL proliferation; DROSOPHILA
- Publication
Frontiers in Cellular Neuroscience, 2015, Vol 8/9, p1
- ISSN
1662-5102
- Publication type
Article
- DOI
10.3389/fncel.2014.00443