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- Title
IgA antibodies against [beta]2 glycoprotein I in hemodialysis patients are an independent risk factor for mortality.
- Authors
Serrano A; García F; Serrano M; Ramírez E; Alfaro FJ; Lora D; de la Cámara AG; Paz-Artal E; Praga M; Morales JM
- Abstract
Cardiovascular complications are the most important cause of death in patients on dialysis with end-stage renal disease. Antibodies reacting with [beta]-glycoprotein I seem to play a pathogenic role in antiphospholipid syndrome and stroke and are involved in the origin of atherosclerosis. Here we evaluated the presence of anticardiolipin and anti-[beta]-glycoprotein I antibodies together with other vascular risk factors and their relationship with mortality and cardiovascular morbidity in a cohort of 124 hemodialysis patients prospectively followed for 2 years. Of these, 41 patients were significantly positive for IgA anti-[beta]-glycoprotein I, and the remaining had normal values. At 24 months, overall and cardiovascular mortality and thrombotic events were all significantly higher in patients with high anti-[beta]-glycoprotein I antibodies. Multivariate analysis using Cox regression modeling found that age, hypoalbuminemia, use of dialysis catheters, and IgA [beta]-glycoprotein I antibodies were independent risk factors for death. Thus, IgA antibodies to [beta]-glycoprotein I are detrimental to the clinical outcome of hemodialysis patients.
- Publication
Kidney International, 2012, Vol 81, Issue 12, p1239
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1038/ki.2011.477